Karen Oegema Lab Research

 
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Karen Oegema's lab uses the nematode C. elegans as a model system for mechanistic cell biology, addressing questions in three main areas. The first project area applies high-content screening methods to C. elegans, to build a functional network for the set of ~2500 genes required for embryogenesis. The other two project areas combine experiments in C. elegans and human cells with in vitro biochemistry to dissect the molecular mechanics of cytokinesis and understand the mechanisms underlying centriole duplication and centrosome assembly.