Arshad Desai Lab Research

 
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Arshad Desai's lab investigates the mechanisms that ensure accurate distribution of the replicated genome during cell division. Errors in genome distribution lead to aneuploidy, a cause of birth defects and a hallmark of cancer cells. Specific areas of interest include the epigenetic basis of centromere identity, the mechanics of chromosome-microtubule interactions, the coordination between mechanics and fidelity pathways that ensures accuracy of chromosome segregation, and adaptations that underlie meiotic segregation.